Substance Abuse: Research and Treatment

A Prospective Study to Investigate Predictors of Relapse among Patients with Opioid Use Disorder Treated with Methadone

Submit a Paper

Substance Abuse: Research and Treatment 2016:10 9-18

Original Research

Published on 10 Apr 2016

DOI: 10.4137/SART.S37030

Further metadata provided in PDF

Sign up for email alerts to receive notifications of new articles published in Substance Abuse: Research and Treatment


Introduction: Concomitant opioid abuse is a serious problem among patients receiving methadone maintenance treatment (MMT) for opioid use disorder. This is an exploratory study that aims to identify predictors of the length of time a patient receiving MMT for opioid use disorder remains abstinent (relapse-free).

Methods: Data were collected from 250 MMT patients enrolled in addiction treatment clinics across Southern Ontario. The impact of certain clinical and socio-demographic factors on the outcome (time until opioid relapse) was determined using a Cox proportional hazard model.

Results: History of injecting drug use behavior (hazard ratio (HR): 2.26, P = 0.042), illicit benzodiazepine consumption (HR: 1.07, P = 0.002), and the age of onset of opioid abuse (HR: 1.10, P < 0.0001) are important indicators of accelerated relapse among MMT patients. Conversely, current age is positively associated with duration of abstinence from illicit opioid use, serving as a protective factor against relapse (HR: 0.93, P = 0.003).

Conclusion: This study helps to identify patients at increased risk of relapse during MMT, allowing health care providers to target more aggressive adjunct therapies toward high-risk patients.




Supplementary Files 1   (343.08 KB DOCX FORMAT)

BibTex citation   (BIBDESK, LATEX)


What Your Colleagues Say About Substance Abuse: Research and Treatment
Each promise from the team at Substance Abuse: Research and Treatment has been backed up by action.  Well organized team, prompt cycle times throughout the process of article submission, review, acceptance and article proofs.  You guys have been fantastic.  No wonder you've garnered such a good reputation in such a short time.
Dr Bawo O. James (Department of Clinical Services, Federal Neuro Psychiatric Hospital, Benin City, Edo State, Nigeria)
More Testimonials

Quick Links

New article and journal news notification services