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Evolutionary Bioinformatics

ALFRED: An Allele Frequency Database for Microevolutionary Studies

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Evolutionary Bioinformatics 2005:1 1-10

Published on 22 Feb 2007


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Haseena Rajeevan1, Kei-Hoi Cheung1,2, Rohit Gadagkar2, Shannon Stein1, Usha Soundararajan1, Judith R Kidd1, Andrew J Pakstis1, Perry L Miller2, and Kenneth K Kidd1

1Department of Genetics, Yale University School of Medicine, New Haven, CT 06520-8005, USA. 2Center for Medical Informatics, Yale University School of Medicine, New Haven, CT 06520-8005, USA

Abstract: Many kinds of microevolutionary studies require data on multiple polymorphisms in multiple populations. Increasingly, and especially for human populations, multiple research groups collect relevant data and those data are dispersed widely in the literature. ALFRED has been designed to hold data from many sources and make them available over the web. Data are assembled from multiple sources, curated, and entered into the database. Multiple links to other resources are also established by the curators. A variety of search options are available and additional geographic based interfaces are being developed. The database can serve the human anthropologic genetic community by identifying what loci are already typed on many populations thereby helping to focus efforts on a common set of markers. The database can also serve as a model for databases handling similar DNA polymorphism data for other species.



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