Close
Help




JOURNAL

Biomarker Insights

An Integrative Genomics Approach for Associating Genome-Wide Association Studies Information With Localized and Metastatic Prostate Cancer Phenotypes

Submit a Paper


Biomarker Insights 2017:12 1177271917695810

Original Research

Published on 16 Mar 2017

DOI: 10.1177/1177271917695810


Further metadata provided in PDF



Sign up for email alerts to receive notifications of new articles published in Biomarker Insights

Abstract

High-throughput genotyping has enabled discovery of genetic variants associated with an increased risk of developing prostate cancer using genome-wide association studies (GWAS). The goal of this study was to associate GWAS information of patients with primary organ–confined and metastatic prostate cancer using gene expression data and to identify molecular networks and biological pathways enriched for genetic susceptibility variants involved in the 2 disease states. The analysis revealed gene signatures for the 2 disease states and a gene signature distinguishing the 2 patient groups. In addition, the analysis revealed molecular networks and biological pathways enriched for genetic susceptibility variants. The discovered pathways include the androgen, apoptosis, and insulinlike growth factor signaling pathways. This analysis established putative functional bridges between GWAS discoveries and the biological pathways involved in primary organ–confined and metastatic prostate cancer.



Downloads

PDF  (7.41 MB PDF FORMAT)

RIS citation   (ENDNOTE, REFERENCE MANAGER, PROCITE, REFWORKS)

XML   (124.18 KB XML FORMAT)

BibTex citation   (BIBDESK, LATEX)




Quick Links


New article and journal news notification services