Close
Help





JOURNAL

Evolutionary Bioinformatics

Approximate Likelihood Estimation of Divergence Time Range Using a Coalescent-based Model

Submit a Paper


Evolutionary Bioinformatics 2013:9 499-509

Original Research

Published on 10 Dec 2013

DOI: 10.4137/EBO.S13080


Further metadata provided in PDF



Sign up for email alerts to receive notifications of new articles published in Evolutionary Bioinformatics

Abstract

We present an estimation of divergence time-range based on a coalescent model. This model sum the probability of coalescent trees, taking into account the effect of incomplete lineage sorting. Maximum likelihood estimate based on this model has been computed previously; however, a formula for divergence time-range estimate or confidence interval has never been presented for this model as the expression of the likelihood makes this estimation difficult to compute. Our formula for the divergence time-range estimate can be readily coded into a program. We did not use a simulation or resampling-based approach and therefore our method is fast and less computationally intensive. We demonstrate that our method is much faster and as accurate as a simulation-based approach.



Downloads

PDF  (560.20 KB PDF FORMAT)

RIS citation   (ENDNOTE, REFERENCE MANAGER, PROCITE, REFWORKS)

BibTex citation   (BIBDESK, LATEX)

XML





Quick Links


New article and journal news notification services