Dr. Guinn is a Reader in Biomedical Science at the University of Hull. Dr. Guinn gained her B.Sc. in Genetics from the University of Wales, Aberystwyth in 1991 and a Ph.D. in Medicine from the University of Wales College of Medicine, Cardiff in 1995. Dr. Guinn was one of the first Leukaemia Research Fund Gordon Piller Ph.D. students in the year this prestigious award was initiated. Dr. Guinn undertook two postdoctoral fellowships at the University of Toronto (Autologous Bone Marrow Transplant Unit, Toronto General Hospital and Department of Immunology) and subsequently two senior research fellow posts within the Department of Haematological Medicine at King’s College London and the Cancer Sciences Unit at the University of Southampton. Barbara then joined the University of Bedfordshire as a Reader in Cell Biology and Biochemistry. Barbara has maintained a history of support from cancer charities such as Leukaemia & Lymphoma Research and Cancer Research U.K. and has now published more than 70 peer-reviewed manuscripts. She is on the editorial board of five journals and reviews manuscripts for more than 30 scientific journals on an ad hoc basis.
Dr. Guinn’s research has focused on the identification of tumour antigens and biomarkers in difficult to treat diseases such as ovarian cancer and acute lymphocytic leukaemia using SEREX, microarray and proto-arrays. A number of epitopes from these antigens have been inserted into DNA vaccines and tested for suitability for near-future clinical trials. Dr. Guinn’s group has also worked on tetramer arrays which can demonstrate the presence of tumour antigen-specific T cells in patients and how immune responses change with treatment.
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