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Drug addiction is a chronically relapsing disorder characterized by the compulsive desire to use drugs and a loss of control over consumption. Cannabidiol (CBD), the second most abundant component of cannabis, is thought to modulate various neuronal circuits involved in drug addiction. The goal of this systematic review is to summarize the available preclinical and clinical data on the impact of CBD on addictive behaviors. MEDLINE and PubMed were searched for English and French language articles published before 2015. In all, 14 studies were found, 9 of which were conducted on animals and the remaining 5 on humans. A limited number of preclinical studies suggest that CBD may have therapeutic properties on opioid, cocaine, and psychostimulant addiction, and some preliminary data suggest that it may be beneficial in cannabis and tobacco addiction in humans. Further studies are clearly necessary to fully evaluate the potential of CBD as an intervention for addictive disorders.
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I very much enjoyed the experience of publishing with Substance Abuse: Research and Treatment. The editorial and review staff were very helpful and understanding throughout, even when a very large and complex project was being undertaken, and a range of subjects had to be reviewed. The editor was sympathetic and understanding of the author's responses, and this combined and coordinated interplay has allowed major conceptual advances to be made with major implications for the improvement ...