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Biochemistry Insights

Chemo-Enzymatic Synthesis of Ester-Linked 2-Phenylindole-3-Carboxaldehyde-Monosaccharide Conjugate as Potential Prodrug

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Biochemistry Insights 2012:5 17-20

Original Research

Published on 27 Aug 2012

DOI: 10.4137/BCI.S9961


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Abstract

Chemo-enzymatic synthesis of ester-linked 2-phenylindole-3-carboxaldehyde-glucose conjugate (2-phenylindole-3-carboxyl-10˝-O-β-D-glucosyl ester) was achieved by using plant cell cultures as biocatalysts. The anticancer agent, 2-phenylindole-3-carboxaldehyde, induced apoptosis in cells, whereas 2-phenylindole-3-carboxyl-10˝-O-β-D-glucosyl ester showed no cytotoxicity and induced no apoptosis.



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