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JOURNAL

Gene Regulation and Systems Biology

DNA Conformational Transitions Induced by Supercoiling Control Transcription in Chromatin

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Gene Regulation and Systems Biology 2014:8 89-96

Consise Review

Published on 12 Mar 2014

DOI: 10.4137/GRSB.S13756


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Abstract

Regulation of transcription in eukaryotes is considered in the light of recent findings demonstrating the presence of negative and positive superhelical tension in chromatin. This tension induces conformational transitions in DNA duplex. Particularly, the transition into A-form renders DNA accessible and waylaying for initiation of transcription producing RNA molecules long known to belong to the A-conformation. Competition between conformational transitions in various DNA sequences for the energy of elastic spring opens a possibility for understanding of fine tuning of transcription at a distance.



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