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Magnetic Resonance Insights

Fluorine-19 MRI Contrast Agents for Cell Tracking and Lung Imaging

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Magnetic Resonance Insights 2015:Suppl. 1 53-67

Review

Published on 22 Mar 2016

DOI: 10.4137/MRI.S23559


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Abstract

Fluorine-19 (¹⁹F)-based contrast agents for magnetic resonance imaging stand to revolutionize imaging-based research and clinical trials in several fields of medical intervention. First, their use in characterizing in vivo cell behavior may help bring cellular therapy closer to clinical acceptance. Second, their use in lung imaging provides novel noninvasive interrogation of the ventilated airspaces without the need for complicated, hard-to-distribute hardware. This article reviews the current state of ¹⁹F-based cell tracking and lung imaging using magnetic resonance imaging and describes the link between the methods across these fields and how they may mutually benefit from solutions to mutual problems encountered when imaging ¹⁹F-containing compounds, as well as hardware and software advancements.



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