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JOURNAL

Gene Regulation and Systems Biology

Graphical Modeling Meets Systems Pharmacology

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Gene Regulation and Systems Biology 2017:11 1177625017691937

Perspective

Published on 10 Mar 2017

DOI: 10.1177/1177625017691937


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Abstract

A main source of failures in systems projects (including systems pharmacology) is poor communication level and different expectations among the stakeholders. A common and not ambiguous language that is naturally comprehensible by all the involved players is a boost to success. We present bStyle, a modeling tool that adopts a graphical language close enough to cartoons to be a common media to exchange ideas and data and that it is at the same time formal enough to enable modeling, analysis, and dynamic simulations of a system. Data analysis and simulation integrated in the same application are fundamental to understand the mechanisms of actions of drugs: a core aspect of systems pharmacology.



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