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Environmental Health Insights

Informational Odds Ratio: A Useful Measure of Epidemiologic Association in Environment Exposure Studies

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Environmental Health Insights 2012:6 17-25

Methodology

Published on 03 Apr 2012

DOI: 10.4137/EHI.S9236


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The Editor-in-Chief has endorsed this article

As the Editor-In-Chief of Environmental Health Insights, I endorse this article for 2012 due to its focus on application of Information Odds Ratio epidemiological analysis related to environmental exposures.

Abstract

The informational odds ratio (IOR) measures the post-exposure odds divided by the pre-exposure odds (ie, information gained after knowing exposure status). A desirable property of an adjusted ratio estimate is collapsibility (ie, the combined crude ratio will not change after adjusting for a variable that is not a confounder). Adjusted traditional odds ratios (TORs) are not collapsible. In contrast, Mantel-Haenszel adjusted IORs generally are collapsible. IORs are a useful measure of disease association in environmental case-referent studies, especially when the disease is common in the exposed and/or unexposed groups.



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