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JOURNAL

Cancer Informatics


An international, peer reviewed, open access journal that focuses on reporting bioinformatic analysis of molecular genetic and/or clinical data pertaining to human cancer risk, prevention, outcome or treatment response.  The journal recognizes that scientific collaborations across traditional disciplines can yield exponential synergistic gains: cancer research benefits from advances in many fields, including genomics and proteomics, mass spectrometry and radio imaging, computer science and biostatistics including machine learning and artificial intelligence, and medical informatics. The journal also recognizes the centrality of computational biology in these synergies.

Editor in Chief: Dr. J. T. Efird

ISSN: 1176-9351

Processing Speed: High quality, constructive peer review and rapid editorial decision within an average of four weeks.



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Article Search

Penalized Ordinal Regression Methods for Predicting Stage of Cancer in High-Dimensional Covariate Spaces
Amanda Elswick Gentry, Colleen K. Jackson-Cook, Debra E. Lyon and Kellie J. Archer
Cancer Informatics 2015:Suppl. 2 201-208
Review | Published on 27 May 2015



Perturbation of Interaction Networks for Application to Cancer Therapy
Adrian P. Quayle, Asim S. Siddiqui and Steven J. M. Jones
Cancer Informatics 2007:5 45-65
Published on 01 Apr 2007



DICOM Structured Reporting and Cancer Clinical Trials Results
David A. Clunie
Cancer Informatics 2007:4 33-56
Published on 12 May 2007



TNBCtype: A Subtyping Tool for Triple-Negative Breast Cancer
Xi Chen, Jiang Li, William H. Gray, Brian D. Lehmann, Joshua A. Bauer, Yu Shyr, and Jennifer A. Pietenpol
Cancer Informatics 2012:11 147-156
Case report | Published on 24 Jul 2012



GENT: Gene Expression Database of Normal and Tumor Tissues
Gwangsik Shin, Tae-Wook Kang, Sungjin Yang, Su-Jin Baek, Yong-Su Jeong and Seon-Young Kim
Cancer Informatics 2011:10 149-157
Database Review | Published on 09 May 2011



The Bimodality Index: A Criterion for Discovering  and Ranking Bimodal Signatures from Cancer Gene Expression Profiling Data
Jing Wang, Sijin Wen, W. Fraser Symmans, Lajos Pusztai and Kevin R. Coombes
Cancer Informatics 2009:7 199-216
Original Research | Published on 05 Aug 2009



Germinal Center B Cell-Like (GCB) and Activated B Cell-Like (ABC) Type of Diffuse Large B Cell Lymphoma (DLBCL): Analysis of Molecular Predictors, Signatures, Cell Cycle State and Patient Survival
S. Blenk, J. Engelmann, M. Weniger, J. Schultz, M. Dittrich, A. Rosenwald, H.K. Müller-Hermelink, T. Müller and T. Dandekar
Cancer Informatics 2007:3 399-420
Published on 12 Dec 2007



Microarray-Based Cancer Prediction Using Soft Computing Approach
Xiaosheng Wang and Osamu Gotoh
Cancer Informatics 2009:7 123-139
Original Research | Published on 26 May 2009



Mathematical Prognostic Biomarker Models for Treatment Response and Survival in Epithelial Ovarian Cancer
Jason B. Nikas, Kristin L.M. Boylan, Amy P.N. Skubitz, and Walter C. Low
Cancer Informatics 2011:10 233-247
Original Research | Published on 03 Oct 2011



PCCR: Pancreatic Cancer Collaborative Registry
Simon Sherman, Oleg Shats, Marsha A. Ketcham, Michelle A. Anderson, David C. Whitcomb, Henry T. Lynch, Paola Ghiorzo, Wendy S. Rubinstein, Aaron R. Sasson, William E. Grizzle, Gleb Haynatzki, Jianmin Feng, Alexander Sherman, Leo Kinarsky and Randall E. Brand
Cancer Informatics 2011:10 83-91
Original Research | Published on 23 Mar 2011



Protein-protein Interaction Reveals Synergistic Discrimination of Cancer Phenotype
Jianghui Xiong, Juan Liu, Simon Rayner, Yinghui Li and Shanguang Chen
Cancer Informatics 2010:9 61-66
Original Research | Published on 26 Mar 2010



Comparison of a Label-Free Quantitative Proteomic Method Based on Peptide Ion Current Area to the Isotope Coded Affinity Tag Method
Soyoung Ryu, Byron Gallis, Young Ah Goo, Scott A. Shaffer, Dragan Radulovic, David R. Goodlett
Cancer Informatics 2008:6 243-255
Published on 17 Apr 2008



Applications of Microarray Technology to Acute Myelogenous Leukemia
Rashmi S. Goswami, Mahadeo A. Sukhai, Mariam Thomas, Patricia P. Reis and Suzanne Kamel-Reid
Cancer Informatics 2009:7 13-28
Review | Published on 22 Dec 2008



A Novel Cross-Disciplinary Multi-Institute Approach to Translational Cancer Research: Lessons Learned from Pennsylvania Cancer Alliance Bioinformatics Consortium (PCABC)
Ashokkumar A. Patel, John R. Gilbertson, Louise C. Showe, Jack W. London, Eric Ross, Michael F. Ochs, Joseph Carver, Andrea Lazarus, Anil V. Parwani, Rajiv Dhir, J. Robert Beck, Michael Liebman, Fernando U. Garcia, Jeff Prichard, Myra Wilkerson, Ronald B. Herberman, Michael J. Becich, and the PCABC.
Cancer Informatics 2007:3 255-274
Published on 08 Jun 2007



Evaluating Microarray-based Classifiers: An Overview
A.-L. Boulesteix, C. Strobl, T. Augustin and M. Daumer
Cancer Informatics 2008:6 77-97
Published on 29 Feb 2008



Robust Model Selection for Classification of Microarrays
Ikumi Suzuki, Takashi Takenouchi, Miki Ohira, Shigeyuki Oba and Shin Ishii
Cancer Informatics 2009:7 141-157
Original Research | Published on 25 Jun 2009



Multicenter Breast Cancer Collaborative Registry
Simon Sherman, Oleg Shats, Elizabeth Fleissner, George Bascom, Kevin Yiee, Mehmet Copur, Kate Crow, James Rooney, Zubeena Mateen, Marsha A. Ketcham, Jianmin Feng, Alexander Sherman, Michael Gleason, Leo Kinarsky, Edibaldo Silva-Lopez, James Edney, Elizabeth Reed, Ann Berger and Kenneth Cowan
Cancer Informatics 2011:10 217-226
Methodology | Published on 31 Aug 2011



Classifying Variants of Undetermined Significance in BRCA2 with Protein Likelihood Ratios
Rachel Karchin, Mukesh Agarwal, Andrej Sali, Fergus Couch and Mary S. Beattie
Cancer Informatics 2008:6 203-216
Published on 18 Apr 2008



Integrated Analysis Reveals hsa-miR-142 as a Representative of a Lymphocyte-Specific Gene Expression and Methylation Signature
Bill Andreopoulos and Dimitris Anastassiou
Cancer Informatics 2012:11 61-75
Original Research | Published on 12 Mar 2012



Use of Gene Expression Profiles of Peripheral Blood Lymphocytes to Distinguish BRCA1 Mutation Carriers in High Risk Breast Cancer Families
Marie-Laure Vuillaume, Nancy Uhrhammer, Véronique Vidal, Valérie Sylvain Vidal, Valérie Chabaud, Beline Jesson, Fabrice Kwiatkowski and Yves-Jean Bignon
Cancer Informatics 2009:7 41-56
Published on 02 Mar 2009



On Differential Gene Expression Using RNA-Seq Data
Juhee Lee, Yuan Ji, Shoudan Liang, Guoshuai Cai and Peter Müller
Cancer Informatics 2011:10 205-215
Methodology | Published on 01 Aug 2011



Haploinsufficiency of Tumor Suppressor Genes is Driven by the Cumulative Effect of microRNAs, microRNA Binding Site Polymorphisms and microRNA Polymorphisms: An In silico Approach
Mayakannan Manikandan, Ganesh Raksha and Arasambattu Kannan Munirajan
Cancer Informatics 2012:11 157-171
Perspective | Published on 29 Aug 2012



Linear Discriminant Functions in Connection with the micro-RNA Diagnosis of Colon Cancer
Jason B. Nikas and Walter C. Low
Cancer Informatics 2012:11 1-14
Original Research | Published on 20 Dec 2011



Skin Cancer Recognition by Using a Neuro-Fuzzy System
Bareqa Salah, Mohammad Alshraideh, Rasha Beidas and Ferial Hayajneh
Cancer Informatics 2011:10 1-11
Original Research | Published on 02 Feb 2011



An Integrative Analysis of microRNA and mRNA Expression - A Case Study
Li-Xuan Qin
Cancer Informatics 2008:6 369-379
Published on 17 Jun 2008



Inhibition of Antiapoptotic BCL-XL, BCL-2, and MCL-1 Proteins by Small Molecule Mimetics
D.S. Dalafave and G. Prisco
Cancer Informatics 2010:9 169-177
Original Research | Published on 12 Aug 2010



Effect of Quantitative Nuclear Image Features on Recurrence of Ductal Carcinoma In Situ (DCIS) of the Breast
David E. Axelrod, Naomi A. Miller, H. Lavina Lickley, Jin Qian, William A. Christens-Barry, Yan Yuan, Yuejiao Fu and Judith-Anne W. Chapman
Cancer Informatics 2008:6 99-109
Published on 01 Mar 2008



Optimal Network Alignment with Graphlet Degree Vectors
Tijana Milenković, Weng Leong Ng, Wayne Hayes and Nataša Pržulj
Cancer Informatics 2010:9 121-137
Original Research | Published on 30 Jun 2010



Investigation of miRNA Biology by Bioinformatic Tools and Impact of miRNAs in Colorectal Cancer: Regulatory Relationship of c-Myc and p53 with miRNAs
Yaguang Xi, John R. Edwards and Jingfang Ju
Cancer Informatics 2007:3 245-253
Published on 31 May 2007



DNA Copy Number Analysis in Gastrointestinal Stromal Tumors Using Gene Expression Microarrays
Cristina R. Antonescu, Kai Wu, Guoliang Leon Xing, Manqiu Cao, Yaron Turpaz, Margaret A. Leversha, Earl Hubbell, Robert G. Maki, C. Garrett Miyada, and Raji Pillai
Cancer Informatics 2008:6 59-75
Published on 27 Mar 2008



Non-Negative Matrix Factorization for the Analysis of Complex Gene Expression Data: Identification of Clinically Relevant Tumor Subtypes
Attila Frigyesi and Mattias Höglund
Cancer Informatics 2008:6 275-292
Published on 29 May 2008



Dual KS: Defining Gene Sets with Tissue Set Enrichment Analysis
Yarong Yang, Eric J. Kort, Nader Ebrahimi, Zhongfa Zhang and Bin T. Teh
Cancer Informatics 2010:9 1-9
Methodology | Published on 21 Jan 2010



Comparison of Supervised Classification Methods for Protein Profiling in Cancer Diagnosis
Nadège Dossat, Alain Mangé, Jérôme Solassol, William Jacot, Ludovic Lhermitte, Thierry Maudelonde, Jean-Pierre Daurès and Nicolas Molinari
Cancer Informatics 2007:3 295-305
Published on 19 Jul 2007



An Integrative Genomics Approach to Biomarker Discovery in Breast Cancer
Chindo Hicks, Rozana Asfour, Antonio Pannuti and Lucio Miele
Cancer Informatics 2011:10 185-204
Original Research | Published on 25 Jul 2011



The Anti-tumour Agent, Cisplatin, and its Clinically Ineffective Isomer, Transplatin, Produce Unique Gene Expression Profiles in Human Cells
Anne M. Galea and Vincent Murray
Cancer Informatics 2008:6 315-355

Published on 10 Jun 2008



Review of Current Methods, Applications, and Data Management for the Bioinformatics Analysis of Whole Exome Sequencing
Riyue Bao, Lei Huang, Jorge Andrade, Wei Tan, Warren A. Kibbe, Hongmei Jiang and Gang Feng
Cancer Informatics 2014:Suppl. 2 67-82
Review | Published on 21 Sep 2014



A Robust Gene Selection Method for Microarray-based Cancer Classification
Xiaosheng Wang and Osamu Gotoh
Cancer Informatics 2010:9 15-30
Original Research | Published on 04 Feb 2010



Integration of Neuroimaging and Microarray Datasets  through Mapping and Model-Theoretic Semantic Decomposition of Unstructured Phenotypes
Spiro P. Pantazatos, Jianrong Li, Paul Pavlidis and Yves A. Lussier
Cancer Informatics 2009:8 75-94
Original Research | Published on 08 Jun 2009



New Advanced Technologies to Provide Decentralised  and Secure Access to Medical Records: Case Studies  in Oncology
Catherine Quantin, Gouenou Coatrieux, François André Allaert, Maniane Fassa, Karima Bourquard, Jean-Yves Boire, Paul de Vlieger, Lydia Maigne and Vincent Breton
Cancer Informatics 2009:7 217-229
Case Report | Published on 07 Aug 2009



Using Semantic Web Technologies to Annotate and Align Microarray Designs
Sebastian Szpakowski, James McCusker and Michael Krauthammer
Cancer Informatics 2009:8 65-73
Methodology | Published on 13 May 2009



Parametric Power Spectral Density Analysis of Noise from Instrumentation in MALDI TOF Mass Spectrometry
Hyunjin Shin, Miray Mutlu, John M. Koomen and Mia K. Markey
Cancer Informatics 2007:3 219-230
Published on 17 Sep 2007



Estrogen Exposure, Metabolism, and Enzyme Variants in a Model for Breast Cancer Risk Prediction
Fritz F. Parl, Kathleen M. Egan, Chun Li and Philip S. Crooke
Cancer Informatics 2009:7 109-121
Original Research | Published on 05 May 2009



Data Mining for Gene Networks Relevant to Poor Prognosis in Lung Cancer via Backward-Chaining Rule Induction
Mary E. Edgerton, Douglas H. Fisher, Lianhong Tang, Lewis J. Frey and Zhihua Chen

Cancer Informatics 2007:3 93-114


Published on 10 Feb 2007



Combining Clinical and Genomic Covariates via Cov-TGDR
Shuangge Ma and Jian Huang
Cancer Informatics 2007:3 371-378
Published on 15 Oct 2007



Unblocking Blockbusters: Using Boolean Text-Mining to Optimise Clinical Trial Design and Timeline for Novel Anticancer Drugs
Richard J. Epstein
Cancer Informatics 2009:7 231-238

Original Research | Published on 17 Aug 2009



Comparisons of Robustness and Sensitivity between Cancer and Normal Cells by Microarray Data
Liang-Hui Chu and Bor-Sen Chen
Cancer Informatics 2008:6 165-181
Published on 28 Mar 2008



OmicCircos: A Simple-to-Use R Package for the Circular Visualization of Multidimensional Omics Data
Ying Hu, Chunhua Yan, Chih-Hao Hsu, Qing-Rong Chen, Kelvin Niu, George A. Komatsoulis and Daoud Meerzaman
Cancer Informatics 2014:13 13-20
Technical Advance | Published on 16 Jan 2014



Evaluating Translocation Gene Fusions by SNP Array Data
Hong Liu, Asher Zilberstein, Pascal Pannier, Frederic Fleche, Christopher Arendt, Christoph Lengauer and Chang S. Hahn
Cancer Informatics 2012:11 15-27
Original Research | Published on 21 Dec 2011



Uncovering Biological Network Function via Graphlet Degree Signatures
Tijana Milenković and Nataša Pržulj
Cancer Informatics 2008:6 257-273

Published on 14 Apr 2008



Efficiency Analysis of Competing Tests for Finding Differentially Expressed Genes in Lung Adenocarcinoma
Rick Jordan, Satish Patel, Hai Hu, and James Lyons-Weiler
Cancer Informatics 2008:6 389-421

Published on 14 Jul 2008





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