Close
Help





JOURNAL

Magnetic Resonance Insights

Longitudinal Brain Size Measurements in APP/PS1 Transgenic Mice

Submit a Paper


Magnetic Resonance Insights 2010:4 19-26

Original Research

Published on 08 Oct 2010

DOI: 10.4137/MRI.S5885


Further metadata provided in PDF



Sign up for email alerts to receive notifications of new articles published in Magnetic Resonance Insights

Abstract

There appear to be species differences among the effects of gene mutations related to familial Alzheimer’s disease on the brain during aging. To gain a better understanding of the effects of the Swedish mutation of amyloid precursor protein and the mutant form of human presenilin 1 on mice, commercially available mice from Jackson Laboratory were studied. Three dimensional T2*-weighted imaging was used to monitor the size of brains of APP/PS1 mice monthly, from 6 to 13 months of age. No significant difference was measured in the size of the medial-lateral width, dorsal-ventral height, rostral-caudal length or the volume of the APPSwe/ PS1 mouse brain. Faster and higher-resolution imaging methods are needed to accurately determine if small volume or shape changes occur in mouse brains with age or gene mutations.



Downloads

PDF  (740.76 KB PDF FORMAT)

RIS citation   (ENDNOTE, REFERENCE MANAGER, PROCITE, REFWORKS)

BibTex citation   (BIBDESK, LATEX)





Quick Links


New article and journal news notification services