Close
Help




JOURNAL

Translational Oncogenomics

Roles of Prohibitin in Growth Control and Tumor Suppression in Human Cancers

Submit a Paper


Translational Oncogenomics 2008:3 23-37

Published on 10 Feb 2008


Further metadata provided in PDF



Sign up for email alerts to receive notifications of new articles published in Translational Oncogenomics

Sheng Wang and Douglas V. Faller

Boston University School of Medicine, Cancer Research Center, Boston, MA, U.S.A.

Abstract

Tumor formation results from alterations in the normal control of cell proliferation. In the past decade, much attention in cancer research has been focused on the function of proto-oncogenes and tumor suppressors. Prohibitin is a potential tumor suppressor which was originally identifi ed because of its anti-proliferative activities. Subsequent investigations led to the discovery of prohibitin mutations in sporadic breast cancers. Recent studies established that prohibitin directly regulates E2F-mediated transcription and growth suppression Prohibitin further attracted the attention of the translational cancer research community when it was recently connected to the regulation of estrogen receptor and androgen receptor activity. Prohibitin was shown to be required for the growth suppression of breast cancer cells induced by estrogen antagonists, and for therapeutic responses to androgen antagonists in prostate cancer. Through the application of new molecular technologies, additional novel functions of prohibitin have been revealed, demonstrating diverse and essential roles of this highly-conserved protein in regulating cell growth.



Downloads

PDF  (582.57 KB PDF FORMAT)

RIS citation   (ENDNOTE, REFERENCE MANAGER, PROCITE, REFWORKS)

BibTex citation   (BIBDESK, LATEX)

XML




Quick Links


New article and journal news notification services