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JOURNAL

Breast Cancer: Basic and Clinical Research

Targeting Breast Cancer Metastasis

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Breast Cancer: Basic and Clinical Research 2015:Suppl. 1 23-34

Review

Published on 02 Sep 2015

DOI: 10.4137/BCBCR.S25460


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Abstract

Metastasis is the leading cause of breast cancer-associated deaths. Despite the significant improvement in current therapies in extending patient life, 30–40% of patients may eventually suffer from distant relapse and succumb to the disease. Consequently, a deeper understanding of the metastasis biology is key to developing better treatment strategies and achieving long-lasting therapeutic efficacies against breast cancer. This review covers recent breakthroughs in the discovery of various metastatic traits that contribute to the metastasis cascade of breast cancer, which may provide novel avenues for therapeutic targeting.



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