Breast Cancer: Basic and Clinical Research

The Efficacy of Intraoperative Frozen Section Analysis During Breast-Conserving Surgery for Patients with Ductal Carcinoma In Situ

Submit a Paper

Breast Cancer: Basic and Clinical Research 2016:10 205-210

Original Research

Published on 08 Dec 2016

DOI: 10.4137/BCBCR.S40868

Further metadata provided in PDF

Sign up for email alerts to receive notifications of new articles published in Breast Cancer: Basic and Clinical Research


Introduction: Recently, the incidence of ductal carcinoma in situ (DCIS), a noninvasive breast malignancy, has increased. This has resulted in an increase in the incidence of breast-conserving surgery (BCS). Numerous studies have suggested that intraoperative frozen section analysis (IFSA) could reduce the rate of additional excisions required to obtain adequate resection margins. However, DCIS is a known risk factor for positive margin status during BCS. Furthermore, some authors have concluded that IFSA may not be reliable for the detection of DCIS.

Aim: The aim of this study was to evaluate the safety and efficacy of IFSA in patients with DCIS.

Methods: The operative and pathological reports of patients with DCIS, who underwent BCS at our institute between 2006 and 2015, were retrospectively reviewed. The results of IFSA and the pathological findings of final reanalyzed frozen tissue specimens were analyzed.

Results: In total, 25 patients were included in our analysis. None of the patients required additional operations. The correct diagnosis rate for IFSA was 89.6%, with a sensitivity and specificity of 60.0% and 95.8%, respectively.

Conclusion: IFSA could be beneficial for determining safety resection margins in patients with DCIS.




BibTex citation   (BIBDESK, LATEX)

What Your Colleagues Say About Breast Cancer: Basic and Clinical Research
We are delighted about the speedy and professional process.
Dr Jan Endrikat (Saarland University Hospital, Germany)
More Testimonials

Quick Links

New article and journal news notification services