Close
Help




JOURNAL

Biomarkers in Cancer

Tissue- and Serum-Associated Biomarkers of Hepatocellular Carcinoma

Submit a Paper


Biomarkers in Cancer 2016:Suppl. 1 37-55

Review

Published on 04 Jul 2016

DOI: 10.4137/BIC.S34413


Further metadata provided in PDF



Sign up for email alerts to receive notifications of new articles published in Biomarkers in Cancer

Abstract

Hepatocellular carcinoma (HCC), one of the leading causes of cancer deaths in the world, is offering a challenge to human beings, with the current modes of treatment being a palliative approach. Lack of proper curative or preventive treatment methods encouraged extensive research around the world with an aim to detect a vaccine or therapeutic target biomolecule that could lead to development of a drug or vaccine against HCC. Biomarkers or biological disease markers have emerged as a potential tool as drug/vaccine targets, as they can accurately diagnose, predict, and even prevent the diseases. Biomarker expression in tissue, serum, plasma, or urine can detect tumor in very early stages of its development and monitor the cancer progression and also the effect of therapeutic interventions. Biomarker discoveries are driven by advanced techniques, such as proteomics, transcriptomics, whole genome sequencing, micro- and micro-RNA arrays, and translational clinics. In this review, an overview of the potential of tissue- and serum-associated HCC biomarkers as diagnostic, prognostic, and therapeutic targets for drug development is presented. In addition, we highlight recently developed micro-RNA, long noncoding RNA biomarkers, and single-nucleotide changes, which may be used independently or as complementary biomarkers. These active investigations going on around the world aimed at conquering HCC might show a bright light in the near future.



Downloads

PDF  (3.32 MB PDF FORMAT)

RIS citation   (ENDNOTE, REFERENCE MANAGER, PROCITE, REFWORKS)

BibTex citation   (BIBDESK, LATEX)

XML




What Your Colleagues Say About Biomarkers in Cancer
Biomarkers in Cancer was prompt, focused and straight forward during the process. Guidance was available throughout the process. This has been one of the most enjoyable experiences in dealing with the staff of a journal publishing good quality science. It's amazing that one day you submit corrections and the next day you receive corrected proofs. And the process continues until you are completely satisfied. Amazing. The peer review process matched the standard of any international ...
Dr Faiz Nasim (Professor of Biochemistry, The Islamia University of Bahawalpur, Pakistan)
More Testimonials

Quick Links


New article and journal news notification services