Biomarker Insights

Biomarker Insights is an international, peer-reviewed, open access journal that aims to support those engaged in biomarker research. It provides the rapid communication of the latest advances in the identification of biomarkers, their application towards the discovery of new knowledge and its clinical application. The journal welcomes unsolicited article proposals. All articles are listed on PubMed and are freely available via PubMed Central.

Editor in Chief: Dr. Karen Pulford

ISSN: 1177-2719

Processing Speed: High quality, constructive peer review and rapid editorial decision within an average of four weeks.

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Changes in Alternative Splicing as Pharmacodynamic Markers for Sudemycin D6
Morgan Thurman, Jacob van Doorn, Barbara Danzer, Thomas R Webb, Stefan Stamm
Biomarker Insights 2017:12 1177271917730557
Short Report | Published on 12 Sep 2017

Inhaled Steroids and Active Smoking Drive Chronic Obstructive Pulmonary Disease Symptoms and Biomarkers to a Greater Degree Than Airflow Limitation
Philip E Silkoff, Dave Singh, J Mark FitzGerald, Andreas Eich, Andrea Ludwig-Sengpiel, Geoffrey C Chupp, Vibeke Backer, Celeste Porsbjerg, Pierre-Olivier Girodet, Mark T Dransfield, Frederic Baribaud, Vedrana S Susulic, Matthew J Loza
Biomarker Insights 2017:12 1177271917730306
Original Research | Published on 07 Sep 2017

Chondroitin Sulfate Inhibits Monocyte Chemoattractant Protein-1 Release From 3T3-L1 Adipocytes: A New Treatment Opportunity for Obesity-Related Inflammation?
Thomas V Stabler, Eulàlia Montell, Josep Vergés, Janet L Huebner, Virginia Byers Kraus
Biomarker Insights 2017:12 1177271917726964
Short Report | Published on 24 Aug 2017

Prognostic Impact of Urokinase Plasminogen Activator Receptor Expression in Pancreatic Cancer: Malignant Versus Stromal Cells
Susanna WL de Geus, Victor M Baart, Martin C Boonstra, Peter JK Kuppen, Hendrica AJM Prevoo, Andrew P Mazar, Bert A Bonsing, Hans Morreau, Cornelis JH van de Velde, Alexander L Vahrmeijer, Cornelis FM Sier
Biomarker Insights 2017:12 1177271917715443
Review | Published on 22 Jun 2017

Making Meaningful Clinical Use of Biomarkers
Matthew J Selleck, Maheswari Senthil, Nathan R Wall
Biomarker Insights 2017:12 1177271917715236
Review | Published on 19 Jun 2017

Influence of Circulating Endothelin-1 and Asymmetric Dimethylarginine on Whole Brain Circulation Time in Multiple Sclerosis
Lucia Monti, Lucia Morbidelli, Lorenzo Bazzani, Alessandro Rossi
Biomarker Insights 2017:12 1177271917712514
Original Research | Published on 06 Jun 2017

Data-Independent Acquisition and Parallel Reaction Monitoring Mass Spectrometry Identification of Serum Biomarkers for Ovarian Cancer
Navin Rauniyar, Gang Peng, TuKiet T Lam, Hongyu Zhao, Gil Mor, Kenneth R Williams
Biomarker Insights 2017:12 1177271917710948
Original Research | Published on 05 Jun 2017

Effects of Acute Exercise on Circulating Soluble Form of the Urokinase Receptor in Patients With Major Depressive Disorder
Anna Gustafsson, Filip Ventorp, Anita GM Wisén, Lars Ohlsson, Lennart Ljunggren, Åsa Westrin
Biomarker Insights 2017:12 1177271917704193
Original Research | Published on 12 Apr 2017

Integrative Analysis of MicroRNA-Mediated Gene Signatures and Pathways Modulating White Blood Cell Count in Childhood Acute Lymphoblastic Leukemia
Ritika Ramani, Gail Megason, Jason Schallheim, Cynthia Karlson, Vani Vijayakumar, Srinivasan Vijayakumar, Chindo Hicks
Biomarker Insights 2017:12 1177271917702895
Original Research | Published on 12 Apr 2017

Hepatocyte Growth Factor/C-Met Axis in Thyroid Cancer: From Diagnostic Biomarker to Therapeutic Target
Maria Trovato, Alfredo Campennì, Salvatore Giovinazzo, Massimiliano Siracusa, Rosaria Maddalena Ruggeri
Biomarker Insights 2017:12 1177271917701126
Consise Review | Published on 30 Mar 2017

Real-Time Reverse-Transcription Quantitative Polymerase Chain Reaction Assay Is a Feasible Method for the Relative Quantification of Heregulin Expression in Non–Small Cell Lung Cancer Tissue
Jessica Kristof, Kellen Sakrison, Xiaoping Jin, Kenji Nakamaru, Matthias Schneider, Robert A Beckman, Daniel Freeman, Cindy Spittle, Wenqin Feng
Biomarker Insights 2017:12 1177271917699850
Original Research | Published on 30 Mar 2017

An Integrative Genomics Approach for Associating Genome-Wide Association Studies Information With Localized and Metastatic Prostate Cancer Phenotypes
Chindo Hicks, Ritika Ramani, Oliver Sartor, Ritu Bhalla, Lucio Miele, Zodwa Dlamini, Njabulo Gumede
Biomarker Insights 2017:12 1177271917695810
Original Research | Published on 16 Mar 2017

Leptomeningeal Carcinomatosis in Gastric Cancer: A Therapeutical Challenge
Maria Vergoulidou
Biomarker Insights 2017:12 1177271917695237
Case report | Published on 16 Mar 2017

A Novel Biomarker Panel to Identify Steroid Resistance in Childhood Idiopathic Nephrotic Syndrome
Michael R Bennett, LaTawnya Pleasant, Christopher Haffner, Qing Ma, Wendy D Haffey, Jun Ying, Michael Wagner, Kenneth D Greis, Prasad Devarajan
Biomarker Insights 2017:12 1177271917695832
Original Research | Published on 08 Mar 2017

Expression of Reactive Oxygen Species–Related Transcripts in Egyptian Children With Autism
Nagwa A Meguid, Said A S Ghozlan, Magda F Mohamed, Marwa K Ibrahim, Reham M Dawood, Noha G Bader El Din, Tawfeek H Abdelhafez, Maha Hemimi, Mostafa K El Awady
Biomarker Insights 2017:12 1177271917691035
Original Research | Published on 23 Feb 2017

Cytochrome P-450 1B1 Leu432Val Polymorphism Does Not Show Association With Breast Cancer in Northern Iranian Women With a History of Infertility
Maryam Ghanbari Andarieh, Ebrahim Zabihi, Dariush Moslemi, Mouloud Agajani Delavar, Mahmoud Haji-Ahmadi, Ali Shabestani Monfared, Seyed Gholam Ali Jorsaraei, Masoumeh Ghasemi, Sedighe Esmaeilzadeh
Biomarker Insights 2017:12 1177271916689058
Original Research | Published on 20 Feb 2017

Soluble P-selectin as a Biomarker for Infection and Survival in Patients With a Systemic Inflammatory Response Syndrome on the Intensive Care Unit
Irene T Schrijver, Hans Kemperman, Mark Roest, Jozef Kesecioglu, Dylan W de Lange
Biomarker Insights 2017:12 1177271916684823
Original Research | Published on 07 Feb 2017

A Comparison of Different Methodologies for the Measurement of Extracellular Vesicles and Milk-derived Particles in Raw Milk from Cows
Geoff Pollott, Amanda Brito, Christopher Gardiner and Charlotte Lawson
Biomarker Insights 2016:11 147-155
Original Research | Published on 13 Dec 2016

Prognostic Value of MammaPrint® in Invasive Lobular Breast Cancer
Inès J. Beumer, Marion Persoon, Anke Witteveen, Christa Dreezen, Suet-Feung Chin, Stephen-John Sammut, Mireille Snel, Carlos Caldas, Sabine Linn, Laura J. van 't Veer, Rene Bernards and Annuska M. Glas
Biomarker Insights 2016:11 139-146
Original Research | Published on 11 Dec 2016

Asymmetric Dimethylarginine and Its Relation As a Biomarker in Nephrologic Diseases
Mustafa E. Sitar
Biomarker Insights 2016:11 131-137
Review | Published on 07 Dec 2016

Procalcitonin Is a Better Biomarker than C-Reactive Protein in Newborns Undergoing Cardiac Surgery: The PROKINECA Study
Sara Bobillo Pérez, Javier Rodríguez-Fanjul, Iolanda Jordan García, Julio Moreno Hernando and Martín Iriondo Sanz
Biomarker Insights 2016:11 123-129
Original Research | Published on 03 Nov 2016

Low Doses of Cisplatin Induce Gene Alterations, Cell Cycle Arrest, and Apoptosis in Human Promyelocytic Leukemia Cells
Venkatramreddy Velma, Shaloam R. Dasari and Paul B. Tchounwou
Biomarker Insights 2016:11 113-121
Original Research | Published on 24 Aug 2016

Plasminogen Activator System and Breast Cancer: Potential Role in Therapy Decision Making and Precision Medicine
Adel Gouri, Aoulia Dekaken, Khalid El Bairi, Arifa Aissaoui, Nihad Laabed, Mohamed Chefrour, Joseph Ciccolini, Gérard Milano and Sadek Benharkat
Biomarker Insights 2016:11 105-111
Review | Published on 16 Aug 2016

Significance of HbA1c Test in Diagnosis and Prognosis of Diabetic Patients
Shariq I. Sherwani, Haseeb A. Khan, Aishah Ekhzaimy, Afshan Masood and Meena K. Sakharkar
Biomarker Insights 2016:11 95-104
Review | Published on 03 Jul 2016

Changes in Urinary and Serum Levels of Novel Biomarkers after Administration of Gadolinium-based Contrast Agents
Habib Mawad, Louis-Philippe Laurin, Jean-François Naud, François A. Leblond, Nathalie Henley, Michel Vallée, Vincent Pichette and Martine Leblanc
Biomarker Insights 2016:11 91-94
Short Report | Published on 29 Jun 2016

Role of Biomarkers in the Diagnosis, Risk Assessment, and Management of Pulmonary Hypertension
Vanessa Rameh and Antoine Kossaify
Biomarker Insights 2016:11 85-89
Short Review | Published on 23 Jun 2016

Precision-Cut Kidney Slices as a Tool to Understand the Dynamics of Extracellular Matrix Remodeling in Renal Fibrosis
Federica Genovese, Zsolt S. Kàrpàti, Signe H. Nielsen and Morten A. Karsdal
Biomarker Insights 2016:11 77-84
Original Research | Published on 22 May 2016

Prediction of the Risk for Essential Hypertension among Carriers of C825T Genetic Polymorphism of G Protein β3 (GNB3) Gene
Neveen Salah El Din Hemimi, Amal A. Mansour and Mona Mohamed Abdelsalam
Biomarker Insights 2016:11 69-75
Original Research | Published on 17 May 2016

Evaluation of Ischemia-Modified Albumin, Malondialdehyde, and Advanced Oxidative Protein Products as Markers of Vascular Injury in Diabetic Nephropathy
Afzal Ahmad, Poornima Manjrekar, Charu Yadav, Ashish Agarwal, Rukmini Mysore Srikantiah and Anupama Hegde
Biomarker Insights 2016:11 63-68
Original Research | Published on 02 May 2016

Proteomic Changes in the Plasma of Broiler Chickens with Femoral Head Necrosis
Balamurugan Packialakshmi, Rohana Liyanage, Jackson O. Lay, Jr., Ronald Okimoto and Narayan C. Rath
Biomarker Insights 2016:11 55-62
Original Research | Published on 27 Apr 2016

Risk of Infectious Complications in Hemato-Oncological Patients Treated with Kinase Inhibitors
Mark Reinwald, Tobias Boch, Wolf-Karsten Hofmann and Dieter Buchheidt
Biomarker Insights 2015:Suppl. 3 55-68
Review | Published on 21 Apr 2016

Heme Oxygenase Activity Correlates with Serum Indices of Iron Homeostasis in Healthy Nonsmokers
Andrew J. Ghio and Dina M. Schreinemachers
Biomarker Insights 2016:11 49-54
Original Research | Published on 19 Apr 2016

Urine Proteome Biomarkers in Kidney Diseases. I. Limits, Perspectives, and First Focus on Normal Urine
Laura Santucci, Maurizio Bruschi, Giovanni Candiano, Francesca Lugani, Andrea Petretto, Alice Bonanni and Gian Marco Ghiggeri
Biomarker Insights 2016:11 41-48
Review | Published on 16 Mar 2016

Management of Chronic Myeloid Leukemia Patients Resistant to Tyrosine Kinase Inhibitors Treatment
Agnieszka Wieczorek and Lutz Uharek
Biomarker Insights 2015:Suppl. 3 49-54
Review | Published on 18 Feb 2016

Histone H3 Phosphorylation in Human Skin Histoculture as a Tool to Evaluate Patient’s Response to Antiproliferative Drugs
Fernando Ugarte, Katherine Porth and Svetlana Sadekova
Biomarker Insights 2015:Suppl. 4 73-76
Original Research | Published on 18 Feb 2016
This article is part of the special collection Gene and Protein Expression Profiling in Disease

Challenges and Current Efforts in the Development of Biomarkers for Chronic Inflammatory and Remodeling Conditions of the Lungs
Gabriele Grunig, Aram Baghdassarian, Sung-Hyun Park, Serhiy Pylawka, Bertram Bleck, Joan Reibman, Erika Berman-Rosenzweig and Nedim Durmus
Biomarker Insights 2015:Suppl. 4 59-72
Review | Published on 16 Feb 2016 | Video abstract
This article is part of the special collection Gene and Protein Expression Profiling in Disease

DNA Subtraction of In Vivo Selected Phage Repertoires for Efficient Peptide Pathology Biomarker Identification in Neuroinflammation Multiple Sclerosis Model
Karina Vargas-Sanchez, Antonios Vekris, and Klaus G. Petry
Biomarker Insights 2016:11 19-29
Original Research | Published on 16 Feb 2016

Assessment of Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Retinol-Binding Protein 4 (RBP4) in Type 2 Diabetic Patients with Nephropathy
Mohamed H. Mahfouz, Adel M. Assiri and Mohammed H. Mukhtar
Biomarker Insights 2016:11 31-40
Original Research | Published on 16 Feb 2016

Isolation of Circulating Tumor Cells from Multiple Epithelial Cancers with ApoStream for Detecting (or Monitoring) the Expression of Folate Receptor Alpha
Daniel J. O'Shannessy, Darren W. Davis, Kenna Anderes and Elizabeth B. Somers
Biomarker Insights 2016:11 7-18
Original Research | Published on 01 Feb 2016

Beyond the Ribosome: Extra-translational Functions of tRNA Fragments
Kevin W. Diebel, Kun Zhou, Aaron B. Clarke and Lynne T. Bemis
Biomarker Insights 2016:Suppl. 1 1-8
Review | Published on 28 Jan 2016

Bioinformatics Resources for MicroRNA Discovery
Alyssa C. Moore, Jonathan S. Winkjer and Tsai-Tien Tseng
Biomarker Insights 2015:Suppl. 4 53-58
Review | Published on 18 Jan 2016
This article is part of the special collection Gene and Protein Expression Profiling in Disease

MicroRNAs Expressed during Viral Infection: Biomarker Potential and Therapeutic Considerations
Jennifer Louten, Michael Beach, Kristina Palermino, Maria Weeks and Gabrielle Holenstein
Biomarker Insights 2015:Suppl. 4 25-52
Review | Published on 18 Jan 2016
This article is part of the special collection Gene and Protein Expression Profiling in Disease

Urinary Vitamin D-Binding Protein as a Biomarker of Steroid-Resistant Nephrotic Syndrome
Michael R. Bennett, Angad Pordal, Christopher Haffner, LaTawnya Pleasant, Qing Ma and Prasad Devarajan
Biomarker Insights 2016:11 1-6
Original Research | Published on 13 Jan 2016

Modeling Kidney Disease with iPS Cells
Benjamin S. Freedman
Biomarker Insights 2015:Suppl. 1 153-169
Review | Published on 22 Dec 2015

Patterns of Local and Systemic Cytokines in Bacterial Meningitis and its Relation with Severity and Long-Term Sequelae
Federico Perdomo-Celis, Miguel A. Torres, Henry Ostos, Javier Gutierrez-Achury, Víctor Molano, Luis F. Durán, Guillermo González, and Carlos F. Narváez
Biomarker Insights 2015:10 125-131
Original Research | Published on 20 Dec 2015

miRNAs As Diagnostic and Prognostic Biomarkers in Pancreatic Ductal Adenocarcinoma and Its Precursor Lesions: A Review
Bárbara Alemar, Cleandra Gregório, and Patricia Ashton-Prolla
Biomarker Insights 2015:10 113-124
Review | Published on 13 Dec 2015

Efficacy of Dasatinib in a CML Patient in Blast Crisis with F317L Mutation: A Case Report and Literature Review
E.V. Morozova, Y.Y. Vlasova, M.V. Pryanishnikova, K.V. Lepik and B.V. Afanasyev
Biomarker Insights 2015:Suppl. 3 43-47
Review | Published on 08 Dec 2015

High Expression of Three-Gene Signature Improves Prediction of Relapse-Free Survival in Estrogen Receptor-Positive and Node-Positive Breast Tumors
Arvind Thakkar, Hemanth Raj, Ravishankar, Bhaskaran Muthuvelan, Arun Balakrishnan and Muralidhara Padigaru
Biomarker Insights 2015:10 103-112
Original Research | Published on 30 Nov 2015

Introductory Editorial: Tyrosine Kinases in Cancer
Olga Blau, Boris Afanasyev, Igor W. Blau
Biomarker Insights 2015:Suppl. 3 41-42
Editorial | Published on 02 Nov 2015

MicroRNA-155 and Its Role in Malignant Hematopoiesis
Prajnya Ranganath
Biomarker Insights 2015:10 95-102
Review | Published on 22 Oct 2015

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