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JOURNAL

International Journal of Tryptophan Research


An international, peer reviewed, open access journal that focuses on all subjects related to tryptophan research, including isolation, functionality, interactions, analysis, synthesis and industrial production, as well as supplementation and role in diet, physiology, neurological disorders and immune response.  Also of interest to the journal are related precursors and metabolites such as serotonin, melatonin, niacin, tryptamine, kynurenine, and indoleamine 2,3-dioxygenase.

Editor in Chief: Professor Gilles Guillemin

ISSN: 1178-6469

Processing Speed: High quality, constructive peer review and rapid editorial decision within an average of four weeks.



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Article Search

2017:10

Interactions of Tryptophan and Its Catabolites With Melatonin and the Alpha 7 Nicotinic Receptor in Central Nervous System and Psychiatric Disorders: Role of the Aryl Hydrocarbon Receptor and Direct Mitochondria Regulation
George Anderson, Michael Maes
International Journal of Tryptophan Research 2017:10 1178646917691738
Original research | Published on 16 Feb 2017



Tryptophan Metabolism in Patients With Chronic Kidney Disease Secondary to Type 2 Diabetes: Relationship to Inflammatory Markers
Subrata Debnath, Chakradhar Velagapudi, Laney Redus, Farook Thameem, Balakuntalam Kasinath, Claudia E Hura, Carlos Lorenzo, Hanna E Abboud, Jason C O’Connor
International Journal of Tryptophan Research 2017:10 1178646917694600
Original research | Published on 10 Mar 2017



Kynurenine Pathway of Tryptophan Metabolism: Regulatory and Functional Aspects
Abdulla A-B Badawy
International Journal of Tryptophan Research 2017:10 1178646917691938
Original research | Published on 15 Mar 2017



Meat Intake and the Dose of Vitamin B – Nicotinamide: Cause of the Causes of Disease Transitions, Health Divides, and Health Futures?
Lisa J Hill, Adrian C Williams
International Journal of Tryptophan Research 2017:10 1178646917704662
Original research | Published on 03 May 2017



Meat and Nicotinamide: A Causal Role in Human Evolution, History, and Demographics
Adrian C Williams, Lisa J Hill
International Journal of Tryptophan Research 2017:10 1178646917704661
Original research | Published on 02 May 2017



Modulation of Tryptophan/Serotonin Pathway by Probiotic Supplementation in Human Immunodeficiency Virus–Positive Patients: Preliminary Results of a New Study Approach
Giuseppe Corano Scheri, Saeid Najafi Fard, Ivan Schietroma, Andrea Mastrangelo, Claudia Pinacchio, Noemi Giustini, Sara Serafino, Gabriella De Girolamo, Eugenio Nelson Cavallari, Maura Statzu, Luca Laghi, Annamaria Vullo, Giancarlo Ceccarelli, Vincenzo Vullo, Gabriella d’Ettorre
International Journal of Tryptophan Research 2017:10 1178646917710668
Original research | Published on 30 May 2017



Aspects of Tryptophan and Nicotinamide Adenine Dinucleotide in Immunity: A New Twist in an Old Tale
Hector Rodriguez Cetina Biefer, Anju Vasudevan, Abdallah Elkhal
International Journal of Tryptophan Research 2017:10 1178646917713491
Original research | Published on 14 Jun 2017



2016:9

Organ Correlation with Tryptophan Metabolism Obtained by Analyses of TDO-KO and QPRT-KO Mice
Katsumi Shibata and Tsutomu Fukuwatari
International Journal of Tryptophan Research 2016:9 1-7
Original research | Published on 28 Apr 2016



Diet Versus Exercise in Weight Loss and Maintenance: Focus on Tryptophan
Barbara Strasser and Dietmar Fuchs
International Journal of Tryptophan Research 2016:9 9-16
Original research | Published on 10 May 2016



Effects of Various Kynurenine Metabolites on Respiratory Parameters of Rat Brain, Liver and Heart Mitochondria
Halina Baran, Katrin Staniek, Melanie Bertignol-Spörr, Martin Attam, Carina Kronsteiner and Berthold Kepplinger
International Journal of Tryptophan Research 2016:9 17-29
Original research | Published on 17 May 2016



Assessment of the Human Kynurenine Pathway: Comparisons and Clinical Implications of Ethnic and Gender Differences in Plasma Tryptophan, Kynurenine Metabolites, and Enzyme Expressions at Baseline and After Acute Tryptophan Loading and Depletion
Abdulla A.-B. Badawy and Donald M. Dougherty
International Journal of Tryptophan Research 2016:9 31-49
Original research | Published on 10 Aug 2016



Tryptophan Metabolism in Rat Liver After Administration of Tryptophan, Kynurenine Metabolites, and Kynureninase Inhibitors
Abdulla A.-B. Badawy and Samina Bano
International Journal of Tryptophan Research 2016:9 51-65
Original research | Published on 11 Aug 2016



The Kynurenine Pathway Is a Double-Edged Sword in Immune-Privileged Sites and in Cancer: Implications for Immunotherapy
Jean-Pierre Routy, Bertrand Routy, Gina M. Graziani and Vikram Mehraj
International Journal of Tryptophan Research 2016:9 67-77
Original research | Published on 12 Oct 2016



Tryptophan Metabolism and Its Relationship with Depression and Cognitive Impairment Among HIV-infected Individuals
Michael R. Keegan, Seetharamaiah Chittiprol, Scott L. Letendre, Alan Winston, Dietmar Fuchs, Adriano Boasso, Jennifer Iudicello and Ronald J. Ellis
International Journal of Tryptophan Research 2016:9 79-88
Original research | Published on 26 Oct 2016



Progesterone Alters Kynurenine Pathway Activation in IFN-γ-Activated Macrophages – Relevance for Neuroinflammatory Diseases
J. de Bie, C. K. Lim and G. J. Guillemin
International Journal of Tryptophan Research 2016:9 89-93
Original research | Published on 07 Dec 2016



2015:8

Enantiomeric Separation of Monosubstituted Tryptophan Derivatives and Metabolites by HPLC with a Cinchona Alkaloid-Based Zwitterionic Chiral Stationary Phase and Its Application to the Evaluation of the Optical Purity of Synthesized 6-Chloro-L-Tryptophan
Takeshi Fukushima, Anna Sugiura, Ippei Furuta, Sumiko Iwasa, Hideaki Iizuka, Hideaki Ichiba, Mayu Onozato, Hidemasa Hikawa and Yuusaku Yokoyama
International Journal of Tryptophan Research 2015:8 1-5
Original research | Published on 07 Jan 2015



The Aryl Hydrocarbon Receptor: A Review of Its Role in the Physiology and Pathology of the Integument and Its Relationship to the Tryptophan Metabolism
Rowland Noakes
International Journal of Tryptophan Research 2015:8 7-18
Original research | Published on 10 Feb 2015



Conversion Percentage of Tryptophan to Nicotinamide is Higher in Rice Protein Diet than in Wheat Protein Diet in Rats
Katsumi Shibata, Tsutomu Fukuwatari and Tomoyo Kawamura
International Journal of Tryptophan Research 2015:8 19-25
Original research | Published on 05 Mar 2015



Tryptophan-Ethylester, the False (Unveiled) Melatonin Isomer in Red Wine
Marcello Iriti and Ileana Vigentini
International Journal of Tryptophan Research 2015:8 27-29
Original research | Published on 30 Mar 2015



Method for Evaluation of the Requirements of B-group Vitamins Using Tryptophan Metabolites in Human Urine
Katsumi Shibata, Junko Hirose and Tsutomu Fukuwatari
International Journal of Tryptophan Research 2015:8 31-39
Original research | Published on 19 Apr 2015



Tryptophan Catabolism in Chronic Viral Infections: Handling Uninvited Guests
Vikram Mehraj and Jean-Pierre Routy
International Journal of Tryptophan Research 2015:8 41-48
Original research | Published on 04 Aug 2015



Chronic Antipsychotic Treatment in the Rat – Effects on Brain Interleukin-8 and Kynurenic Acid
Markus K. Larsson, Lilly Schwieler, Michel Goiny, Sophie Erhardt and Göran Engberg
International Journal of Tryptophan Research 2015:8 49-52
Original research | Published on 20 Sep 2015



2014:7

Kynurenic Acid Levels in Cerebrospinal Fluid from Patients with Alzheimer's Disease or Dementia with Lewy Bodies
Malin Wennström, Henrietta M Nielsen, Funda Orhan, Elisabet Londos, Lennart Minthon and Sophie Erhardt
International Journal of Tryptophan Research 2014:7 1-7
Original research | Published on 28 Apr 2014



Tryptophan and Kynurenic Acid May Produce an Amplified Effect in Central Fatigue Induced by Chronic Sleep Disorder
Masatoshi Yamashita and Takanobu Yamamoto
International Journal of Tryptophan Research 2014:7 9-14
Original research | Published on 14 May 2014



Imbalanced Kynurenine Pathway in Schizophrenia
Magdalena E. Kegel, Maria Bhat, Elisabeth Skogh, Martin Samuelsson, Kristina Lundberg, Marja-Liisa Dahl, Carl Sellgren, Lilly Schwieler, Göran Engberg, Ina Schuppe-Koistinen, and Sophie Erhardt
International Journal of Tryptophan Research 2014:7 15-22
Original research | Published on 16 Sep 2014



Mechanisms of the Pellagragenic Effect of Leucine: Stimulation of Hepatic Tryptophan Oxidation by Administration of Branched-Chain Amino Acids to Healthy Human Volunteers and the Role of Plasma Free Tryptophan and Total Kynurenines
Abdulla A-B Badawy, Sarah L. Lake and Donald M. Dougherty
International Journal of Tryptophan Research 2014:7 23-32
Original research | Published on 04 Dec 2014



2013:Suppl. 1 ISTRY 2013

ISTRY 2013 Special Issue
Gilles J. Guillemin
International Journal of Tryptophan Research 2013:6 (Suppl. 1) 1-2
Original research | Published on 21 Jul 2013



Nutritional Aspect of Tryptophan Metabolism
Tsutomu Fukuwatari and Katsumi Shibata
International Journal of Tryptophan Research 2013:6 (Suppl. 1) 3-8
Original research | Published on 21 Jul 2013



Determination of L-tryptophan and L-kynurenine in Human Serum by using LC-MS after Derivatization with (R)-DBD-PyNCS
Hayato Ohashi, Hideaki Iizuka, Shunsuke Yoshihara, Hayato Otani, Misato Kume, Kiyomi Sadamoto, Hideaki Ichiba and Takeshi Fukushima
International Journal of Tryptophan Research 2013:6 (Suppl. 1) 9-14
Original research | Published on 21 Jul 2013



Role of NAD+, Oxidative Stress, and Tryptophan Metabolism in Autism Spectrum Disorders
Musthafa Mohamed Essa, Selvaraju Subash, Nady Braidy, Samir Al-Adawi, Chai K Lim, Tamilarasan Manivasagam and Gilles J Guillemin
International Journal of Tryptophan Research 2013:6 (Suppl. 1) 15-28
Original research | Published on 21 Jul 2013



Induction of TDO2 and IDO2 in Liver by High-Fat Feeding in Mice: Discrepancies with Human Obesity
Odile Poulain-Godefroy, Elodie Eury, Audrey Leloire, Benjamin Hennart, Gilles J. Guillemin, Delphine Allorge, and Philippe Froguel
International Journal of Tryptophan Research 2013:6 (Suppl. 1) 29-37
Original research | Published on 21 Jul 2013



Kynurenine Pathway Pathologies: do Nicotinamide and Other Pathway Co-Factors have a Therapeutic Role in Reduction of Symptom Severity, Including Chronic Fatigue Syndrome (CFS) and Fibromyalgia (FM)
Adele Blankfield
International Journal of Tryptophan Research 2013:6 (Suppl. 1) 39-45
Original research | Published on 21 Jul 2013



Species and Cell Types Difference in Tryptophan Metabolism
Yuki Murakami and Kuniaki Saito
International Journal of Tryptophan Research 2013:6 (Suppl. 1) 47-54
Original research | Published on 21 Jul 2013



Tryptophan-Restriction Diets Help to Maintain L-Tryptophan Homeostasis in Tryptophan 2,3-Dioxygenase Knockout Mice
Akihiro Maeta, Tsutomu Fukuwatari, Hiroshi Funakoshi, Toshikazu Nakamura and Katsumi Shibata
International Journal of Tryptophan Research 2013:6 (Suppl. 1) 55-65
Original research | Published on 21 Jul 2013



Exploitation of the IDO Pathway in the Therapy of Rheumatoid Arthritis
Richard O. Williams
International Journal of Tryptophan Research 2013:6 (Suppl. 1) 67-73
Original research | Published on 21 Jul 2013



Relationships between Salivary Melatonin Levels, Quality of Sleep, and Stress in Young Japanese Females
Yasuhiro Ito, Tadayuki Iida, Yuumi Yamamura, Mayu Teramura, Yasushi Nakagami, Kaoru Kawai, Yoichi Nagamura and Ryoji Teradaira
International Journal of Tryptophan Research 2013:6 (Suppl. 1) 75-85
Original research | Published on 10 Oct 2013



2013:6

Transport of Kynurenic Acid by Rat Organic Anion Transporters rOAT1 and rOAT3: Species Difference between Human and Rat in OAT1
Yuichi Uwai, Hiroaki Hara and Kikuo Iwamoto
International Journal of Tryptophan Research 2013:6 1-6
Original research | Published on 17 Feb 2013



Characterization of the Kynurenine Pathway and Quinolinic Acid Production in Macaque Macrophages
Chai K. Lim, Margaret M.C. Yap, Stephen J. Kent, Gabriel Gras, Boubekeur Samah, Jane C. Batten, Robert De Rose, Benjamin Heng, Bruce J. Brew, and Gilles J. Guillemin
International Journal of Tryptophan Research 2013:6 7-19
Original research | Published on 15 May 2013



L-Tryptophan Metabolism in Pregnant Mice Fed a High L-Tryptophan Diet and the Effect on Maternal, Placental, and Fetal Growth
Ai Tsuji, Chifumi Nakata, Mitsue Sano, Tsutomu Fukuwatari and Katsumi Shibata
International Journal of Tryptophan Research 2013:6 21-33
Original research | Published on 14 Aug 2013



The Tumor-Selective Cytotoxic Agent ß-Lapachone is a Potent Inhibitor of IDO1
Hollie E. Flick, Judith M. LaLonde, William P. Malachowski and Alexander J. Muller
International Journal of Tryptophan Research 2013:6 35-45
Original research | Published on 19 Aug 2013



Kynurenic Acid in the Digestive System—New Facts, New Challenges
Michal P. Turski, Monika Turska, Piotr Paluszkiewicz, Jolanta Parada-Turska and Gregory F. Oxenkrug
International Journal of Tryptophan Research 2013:6 47-55
Original research | Published on 04 Sep 2013



The Kynurenine Pathway in Stem Cell Biology
Simon P. Jones, Gilles J. Guillemin and Bruce J. Brew
International Journal of Tryptophan Research 2013:6 57-66
Original research | Published on 15 Sep 2013



Effects of Tranilast on the Urinary Excretion of Kynurenic and Quinolinic Acid Under Conditions of L Tryptophan Loading
Rowland R. Noakes
International Journal of Tryptophan Research 2013:6 67-71
Original research | Published on 22 Sep 2013



Big Brains, Meat, Tuberculosis, and the Nicotinamide Switches: Co-Evolutionary Relationships with Modern Repercussions?
Adrian C. Williams and Robin I.M. Dunbar
International Journal of Tryptophan Research 2013:6 73-88
Original research | Published on 15 Oct 2013



Sustained Elevation of Kynurenic Acid in the Cerebrospinal Fluid of Patients with Herpes Simplex Virus Type 1 Encephalitis
Ann Atlas, Elisabeth Franzen-Röhl, Johan Söderlund, Erik G Jönsson, Martin Samuelsson, Lilly Schwieler, Birgit Sköldenberg and Göran Engberg
International Journal of Tryptophan Research 2013:6 89-96
Original research | Published on 25 Nov 2013



Immunohistochemical Studies of the Kynurenine Pathway in Morphea
Rowland Noakes, Nick Mellick
International Journal of Tryptophan Research 2013:6 97-102
Original research | Published on 23 Dec 2013



2012:5

Quinolinic Acid, an Endogenous Molecule Combining Excitotoxicity, Oxidative Stress and Other Toxic Mechanisms
Verónica Pérez-De La Cruz, Paul Carrillo-Mora and Abel Santamaría
International Journal of Tryptophan Research 2012:5 1-8
Original research | Published on 23 Feb 2012



A Jerte Valley Cherry-Based Product as a Supply of Tryptophan
María Garrido, Javier Espino, Antonio F. Toribio-Delgado, Javier Cubero, Juan I. Maynar-Mariño, Carmen Barriga, Sergio D. Paredes and Ana B. Rodríguez
International Journal of Tryptophan Research 2012:5 9-14
Original research | Published on 16 Apr 2012



Kynurenine Pathway in Skin Cells: Implications for UV-Induced Skin Damage
Diba Sheipouri, Nady Braidy, and Gilles J. Guillemin,
International Journal of Tryptophan Research 2012:5 15-25
Original research | Published on 03 Jul 2012



A Brief Historic Overview of Clinical Disorders Associated with Tryptophan: The Relevance to Chronic Fatigue Syndrome (CFS) and Fibromyalgia (FM)
Adele Blankfield
International Journal of Tryptophan Research 2012:5 27-32
Original research | Published on 17 Sep 2012



Fate of Dietary Tryptophan in Young Japanese Women
Chiaki Hiratsuka, Tsutomu Fukuwatari and Katsumi Shibata
International Journal of Tryptophan Research 2012:5 33-47
Original research | Published on 30 Oct 2012



Kynurenic Acid Metabolism in Various Types of Brain Pathology in HIV-1 Infected Patients
H. Baran, J.A. Hainfellner and B. Kepplinger
International Journal of Tryptophan Research 2012:5 49-64
Original research | Published on 13 Dec 2012



2011:4

Tryptophan Oxidative Metabolism Catalyzed by Geobacillus Stearothermophilus: A Thermophile Isolated from Kuwait Soil Contaminated with Petroleum Hydrocarbons
Jassim M. Al-Hassan, Samira Al-Awadi, Sosamma Oommen, Abdulaziz Alkhamis and Mohammad Afzal
International Journal of Tryptophan Research 2011:4 1-6
Original research | Published on 10 Jan 2011



Modulation of Tryptophan Metabolism, Promotion of Neurogenesis and Alteration of Anxiety-Related Behavior in Tryptophan 2,3-Dioxygenase-Deficient Mice
Hiroshi Funakoshi, Masaaki Kanai, and Toshikazu Nakamura
International Journal of Tryptophan Research 2011:4 7-18
Original research | Published on 11 Apr 2011



Tryptophan Transport in Human Fibroblast Cells— A Functional Characterization
Vumma Ravi, Johansson Jessica, Lewander Tommy and Venizelos Nikolaos
International Journal of Tryptophan Research 2011:4 19-27
Original research | Published on 19 Apr 2011



Effects of Kynurenine Pathway Inhibition on NAD+ Metabolism and Cell Viability in Human Primary Astrocytes and Neurons
Nady Braidy, Gilles J. Guillemin and Ross Grant
International Journal of Tryptophan Research 2011:4 29-37
Original research | Published on 08 May 2011



L-Tryptophan Production by Auxotrophic and Analogue Resistant Mutants of Aureobacterium flavescens
A. Roy and S.K. Mukhopadhyay
International Journal of Tryptophan Research 2011:4 39-46
Original research | Published on 29 May 2011



Kynurenine Pathway Hypothesis: The Nature of the Chronic Fatigue Syndrome (CFS) Revisited
Adele Blankfield
International Journal of Tryptophan Research 2011:4 47-48
Original research | Published on 31 Jul 2011



Stochastic Resonance Activity Influences Serum Tryptophan Metabolism in Healthy Human Subjects
Berthold Kepplinger, Halina Baran, Brenda Sedlnitzky-Semler, Nagy-Roland Badawi and Helene Erhart
International Journal of Tryptophan Research 2011:4 49-60
Original research | Published on 08 Nov 2011



2010:3

Role of the NMDA-receptor in Prepulse Inhibition in the Rat
Klas Linderholm, Susan Powell, Elin Olsson, Maria Holtze, Ralph Snodgrass and Sophie Erhardt
International Journal of Tryptophan Research 2010:3 1-12
Original research | Published on 12 Feb 2010



Endogenous Kynurenine Aminotransferases Inhibitor is Proposed to Act as “Glia Depressing Factor” (GDF)
Halina Baran, Berthold Kepplinger and Markus Draxler
International Journal of Tryptophan Research 2010:3 13-22
Original research | Published on 11 May 2010



Specificity of the Acute Tryptophan and Tyrosine Plus Phenylalanine Depletion and Loading Tests I. Review of Biochemical Aspects and Poor Specificity of Current Amino Acid Formulations
Abdulla A.-B. Badawy, Donald M. Dougherty and Dawn M. Richard
International Journal of Tryptophan Research 2010:3 23-34
Original research | Published on 02 Jun 2010



Specificity of the Acute Tryptophan and Tyrosine Plus Phenylalanine Depletion and Loading Tests Part II: Normalisation of the Tryptophan and the Tyrosine Plus Phenylalanine to Competing Amino Acid Ratios in a New Control Formulation
Abdulla A.-B. Badawy, Donald M. Dougherty and Dawn M. Richard
International Journal of Tryptophan Research 2010:3 35-47
Original research | Published on 09 Jun 2010



Editorial ISTRY Special Issue
Gilles J. Guillemin
International Journal of Tryptophan Research 2010:3 49-50
Original research | Published on 10 Jun 2010



On the Biological Importance of the 3-hydroxyanthranilic Acid: Anthranilic Acid Ratio
L. Gail Darlington, Caroline M. Forrest, Gillian M. Mackay, Robert A. Smith, Andrew J. Smith, Nicholas Stoy and Trevor W. Stone
International Journal of Tryptophan Research 2010:3 51-59
Original research | Published on 10 Jun 2010



Accelerated Tryptophan Degradation Predicts Poor Survival in Trauma and Sepsis Patients
Martin Ploder, Andreas Spittler, Katharina Kurz, Gabriele Neurauter, Linda E. Pelinka, Erich Roth and Dietmar Fuchs
International Journal of Tryptophan Research 2010:3 61-67
Original research | Published on 10 Jun 2010



Serum Levels of Tryptophan, 5-Hydroxytryptophan and Serotonin in Patients Affected with Different Forms of Amenorrhea
S. Comai, A. Bertazzo, N. Carretti, A. Podfigurna-Stopa, S. Luisi and C.V.L. Costa
International Journal of Tryptophan Research 2010:3 69-75
Original research | Published on 10 Jun 2010



Indoleamine 2,3-Dioxygenase in Human Hematopoietic Stem Cell Transplantation
Birgit Jürgens, Julia Raberger, Dietmar Fuchs and Andreas Heitger
International Journal of Tryptophan Research 2010:3 77-90
Original research | Published on 10 Jun 2010



Proteasomal Degradation of Indoleamine 2,3-Dioxygenase  in CD8+ Dendritic Cells is Mediated by Suppressor of Cytokine Signaling 3 (SOCS3)
Maria T. Pallotta, Ciriana Orabona, Claudia Volpi, Ursula Grohmann, Paolo Puccetti and Francesca Fallarino
International Journal of Tryptophan Research 2010:3 91-97
Original research | Published on 10 Jun 2010



Effects of Acute Tryptophan Depletion on Three Different Types of Behavioral Impulsivity
Donald M. Dougherty, Dawn M. Richard, Lisa M. James and Charles W. Mathias
International Journal of Tryptophan Research 2010:3 99-111
Original research | Published on 10 Jun 2010



IDO-Mediated Tryptophan Degradation in the Pathogenesis of Malignant Tumor Disease
Robert Sucher, Katharina Kurz, Guenter Weiss, Raimund Margreiter, Dietmar Fuchs and Gerald Brandacher
International Journal of Tryptophan Research 2010:3 113-120
Original research | Published on 10 Jun 2010



Tryptophan, Neurodegeneration and HIV-Associated Neurocognitive Disorder
Nicholas W.S. Davies, Gilles Guillemin and Bruce J. Brew
International Journal of Tryptophan Research 2010:3 121-140
Original research | Published on 10 Jun 2010



Implication of Tryptophan 2,3-Dioxygenase and its Novel Variants in the Hippocampus and Cerebellum During the Developing and Adult Brain
Masaaki Kanai, Hiroshi Funakoshi and Toshikazu Nakamura
International Journal of Tryptophan Research 2010:3 141-149
Original research | Published on 23 Jul 2010



Kynurenine Pathway Metabolism is Involved in the Maintenance of the Intracellular NAD+ Concentration in Human Primary Astrocytes
Ross Grant, Susan Nguyen and Gilles Guillemin
International Journal of Tryptophan Research 2010:3 151-156

Original research | Published on 03 Aug 2010



Understanding the Roles of the Kynurenine Pathway in Multiple Sclerosis Progression
Chai K. Lim, Bruce J. Brew, Gayathri Sundaram and Gilles J. Guillemin
International Journal of Tryptophan Research 2010:3 157-167
Original research | Published on 25 Aug 2010



Alzheimer’s and Seizures: Interleukin-18, Indoleamine 2,3-Dioxygenase and Quinolinic Acid
Anderson G and Ojala JO
International Journal of Tryptophan Research 2010:3 169-173
Original research | Published on 15 Oct 2010



Rapid Isocratic Liquid Chromatographic Separation and Quantification of Tryptophan and Six kynurenine Metabolites in Biological Samples with Ultraviolet and Fluorimetric Detection
Abdulla A-B Badawy and Christopher J Morgan
International Journal of Tryptophan Research 2010:3 175-186
Original research | Published on 08 Dec 2010



2009:2

Kynurenine Pathway Metabolites in Humans: Disease and Healthy States
Yiquan Chen and Gilles J. Guillemin
International Journal of Tryptophan Research 2009:2 1-19
Original research | Published on 08 Jan 2009 | Highly accessed (previous month)



Dedication: Paolo Guidetti
Robert Schwarcz
International Journal of Tryptophan Research 2009:2 21-22
Original research | Published on 16 Feb 2009



Assessment of the Potential Role of Tryptophan as the Precursor of Serotonin and Melatonin for the Aged Sleep-wake Cycle and Immune Function: Streptopelia Risoria as a Model
Sergio D. Paredes, Carmen Barriga, Russel J. Reiter and Ana B. Rodríguez
International Journal of Tryptophan Research 2009:2 23-36
Original research | Published on 14 Jan 2009



Production and Peripheral Roles of 5-HTP, a Precursor of Serotonin
Kazuhiro Nakamura and Hiroyuki Hasegawa
International Journal of Tryptophan Research 2009:2 37-43
Original research | Published on 30 Mar 2009



L -Tryptophan: Basic Metabolic Functions, Behavioral Research and Therapeutic Indications
Dawn M Richard, Michael A Dawes, Charles W Mathias, Ashley Acheson, Nathalie Hill-Kapturczak and Donald M Dougherty
International Journal of Trytophan Research 2009:2 45-60
Original research | Published on 23 Mar 2009



Effects of Kynurenine Pathway Metabolites on Intracellular NAD+ Synthesis and Cell Death in Human Primary Astrocytes and Neurons

Nady Braidy, Ross Grant, Bruce J Brew, Seray Adams, Tharusha Jayasena and Gilles J. Guillemin


International Journal of Tryptophan Research 2009:2 61-69


Original research | Published on 03 Apr 2009



The Physiological Action of Picolinic Acid in the Human Brain
R.S. Grant, S.E. Coggan and G.A. Smythe
International Journal of Tryptophan Research 2009:2 71-79
Original research | Published on 28 Apr 2009



2008:1

Introductory Editorial (International Journal of Tryptophan Research)
Gilles J. Guillemin
International Journal of Tryptophan Research 2008:1 1
Original research | Published on 09 Apr 2008



Tryptophan Research in Panic Disorder
Eduard Maron, Jakov Shlik and David J. Nutt
International Journal of Tryptophan Research 2008:1 3-12
Original research | Published on 14 Aug 2008





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