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Clinical Medicine Insights: Oncology

Non-Hodgkin Lymphoma of the Stomach in a Patient Treated with Natalizumab

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Clinical Medicine Insights: Oncology 2015:9 61-63

Case report

Published on 01 Jul 2015

DOI: 10.4137/CMO.S27142


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Abstract

A 61-year-old man with relapsing-remitting multiple sclerosis developed extranodal large B-cell lymphoma of the stomach following monthly natalizumab infusions for 6 years. Development of lymphoproliferative disorders increases with chronic use of immunosuppression. Cases of primary central nervous system lymphoma as well as one case of peripheral T-cell lymphoma have previously been reported with natalizumab use. Given the absence of a known association between multiple sclerosis and extranodal presentations of diffuse large B-cell lymphoma, a causal association with natalizumab administration cannot be excluded.



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